Cultured sensory neuron axons, fluorescence microscopy, black and white

Skin biopsy analysis for small fibre neuropathy

Patients Clinics

Sensory Neuron Analysis & Research Laboratory · Croatia

SNARE Lab is an independent research laboratory that performs the analysis. Partner clinics take the biopsy; we quantify the nerve fibres and report to the physician.

PGP9.5-stained skin section with nerve fibres crossing into the epidermis, black and white

Intraepidermal nerve fibre density (IENFD) is the number of small nerve fibres crossing into the epidermis per millimetre of skin section, counted under a microscope in a skin biopsy stained for the nerve marker PGP9.5. Further reading: Kool D, Anđelić M, Lombardi R, Hoeijmakers JGJ, Faber CG, Lauria G. Skin Biopsy. Encyclopedia of the Neurological Sciences, 3rd ed., Vol. 4. Elsevier, 2025.

Trained at Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, and the School for Mental Health and Neuroscience (MHeNs), Maastricht University · EFNS/PNS 2010 protocol · Independent research laboratory, Croatia